NIOSH pages 12/19

Muscle pain is often experienced by workers who have to move repeatedly and/or forcibly. The cumulative trauma disorder that results from repetitive movements is difficult to anticipate and prevent. The present study uses a rodent model to: (1) determine the factors which produce dysfunctional muscles, (2) document changes in the matrix and myofibers which lead to pathologic muscles, and (3) study the impact of speed and acceleration on the function and reversibility of repeated injury experienced by hand-intensive jobs. In this research, muscles are chronically injured by mechanical overloading. Tissues are surveyed for specific cellular markers involved in tissue injury and repair. The functional outcome of repeated injury is assessed. This research will aid in the design of preventive regimens for individuals in specific industrial settings. Age and Cumulative Trauma Disorder in Garment Workers Researcher: Jacqueline Agnew, Ph.D. Affiliation: Johns Hopkins University Baltimore, Maryland (410) 955-4082